WITHDRAWN: Two dimensional and k-nearest neighbor molecular field analysis approach on substituted Triazolone derivatives: An insight into the structural requirement for the angiotensin II receptor antagonist
نویسندگان
چکیده
منابع مشابه
Rationalization of Physicochemical and Structural Requirement of Some Substituted 5-(Biphenyl-4-ylmethyl)Pyrazole as Angiotensin II Receptor Antagonist: A QSAR Approach
A series of angiotensin II (A II) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to QSAR analysis using Hansch and Fujita-Ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. Several QSAR model were obtained using stepwise regression analysis. Two models from both the ...
متن کاملQSAR Study on Novel CCR5 Receptor Antagonists: An Insight into the Structural Requirement for the HIV Co Receptor Antagonist Activity
Chemokines receptors have emerged as important drug targets for development of agents against the HIV/AIDS pandemic. With the purpose of designing new chemical entities with enhanced antagonistic potencies against the CCR5 chemokine receptor, the QSAR study carried out on 70 novel phenoxybenzyl derivatives as antagonists of CCR5 HIV co receptor is presented. The developed model was validated by...
متن کاملrationalization of physicochemical and structural requirement of some substituted 5-(biphenyl-4-ylmethyl)pyrazole as angiotensin ii receptor antagonist: a qsar approach
a series of angiotensin ii (a ii) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to qsar analysis using hansch and fujita-ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. several qsar model were obtained using stepwise regression analysis. two models from both the method...
متن کاملTwo-dimensional nearest neighbor discriminant analysis
Recently, some feature extraction methods have been developed by representing images with matrix directly, however few of them are proposed to improve accuracy of classification directly. In this paper, a novel feature extraction method, twodimensional nearest neighbor discriminant analysis(2DNNDA), is proposed from the view of the nearest neighbor classification, which makes use of the matrix ...
متن کاملMolecular Insight into the Mutual Interactions of Two Transmembrane Domains of Human Glycine Receptor (TM23-GlyR), with the Lipid Bilayers
Appearing as a computational microscope, MD simulation can ‘zoom in’ to atomic resolution to assess detailed interactions of a membrane protein with its surrounding lipids, which play important roles in the stability and function of such proteins. This study has employed the molecular dynamics (MD) simulations, to determine the effect of added DMPC or DMTAP molecules on the structure of D...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2011
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2011.10.008